Hepatitis B Core Antibody, Total (006718)

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Category:

Turnaround Time: 1 - 2 days
CPT Code:

86704

Test Type: 1 mL Serum or plasma
Stability Time:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Reference Range:

Negative

Overview:

Aid in the diagnosis of acute or chronic hepatitis B virus (HBV) infection and in the determination of the clinical status of HBV infected individuals in conjunction with other HBV serological markers. Aid in differential diagnosis of hepatitis. The presence of anti-HBc total antibody indicates previous or ongoing infection with HBV in an undefined time frame.

AuBuchon JP, Sandler SG, Fang CT, Dodd RY. American Red Cross experience with routine testing for hepatitis B core antibody. Transfusion. 1989 Mar-Apr; 29(3):230-232. PubMed 2493695

Chambers LA, Popovsky MA. Decrease in reported post-transfusion hepatitis. Contributions of donor screening for alanine aminotransferase and antibodies to hepatitis B core antigen and changes in the general population. Arch Intern Med. 1991 Dec; 151(12):2445-2448. PubMed 1747001

Edwards MS. Hepatitis B serology—help in interpretation. Pediatr Clin North Am. 1988 Jun; 35(3):503-515 (review). PubMed 3287312

Gupta S, Govindarajan S, Fong TL, Redeker AG. Spontaneous reactivation in chronic hepatitis B: patterns and natural history. J Clin Gastroenterol. 1990 Oct; 12(5):562-568. PubMed 2230000

Lee HS, Vyas GN. Diagnosis of viral hepatitis. Clin Lab Med. 1987 Dec; 7(4):741-757 (review). PubMed 3319367

Mushahwar IK, Dienstag JL, Polesky HF, McGrath LC, Decker RH, Overby LR. Interpretation of various serological profiles of hepatitis B virus infection. Am J Clin Pathol. 1981 Dec; 76(6):773-777. PubMed 7315794

Collection Details:

Collection Instructions:

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube.

If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.

Room temperature.