Insulin-like Growth Factor-binding Protein 1 (IGFBP-1)

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Turnaround Time: 6 - 12 days
CPT Code:


Test Type: 0.5 mL Serum, frozen
Stability Time:



Room temperature

1 day


2 days


16 months

Freeze/thaw cycles

Stable x6


Identify women who are at high risk for developing preëclampsia.

Insulin-like growth factor-binding protein 1 is a member of the family of structurally homologous proteins that specifically binds and modulates the activities of IGF-1 and IGF-2.1,2 IGFBP-1 is a 25 kilodalton protein that is produced predominantly by hepatocytes and decidualized ovarian endometrium.3 Serum levels of IGFBP-1 exhibit considerable diurnal variation with levels highest early in the morning and lowest in the evening. Serum IGFBP-1 levels are controlled by insulin with the postprandial increase in insulin levels producing a four- to fivefold decrease in IGFBP-1 levels relative to fasting levels.1 IGFBP-1 levels have been shown to be elevated in type 1 diabetics and in patients with insulin resistance syndromes. Type 2 diabetics tend to have low serum IGFBP-1 levels. Patients with growth hormone deficiency tend to have elevated IGFBP-1 levels. Low levels are observed in acromegaly, Cushing disease, and polycystic ovary syndrome. IGFBP-1 is the predominant IGF-binding protein in amniotic fluid and in fetal and maternal circulation.4,5 The levels are high in the fetus and newborn, but decline steadily until puberty. In a recent study of women in the second trimester of pregnancy, IGFBP-1 levels were higher in women who subsequently developed preëclampsia than in matched controls who did not develop the syndrome.6

1. Clemmons DR. Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev. 1997 Mar; 8(1):45-62 (review). PubMed 9174662

2. Ranke MB, Elmlinger M. Functional role of insulin-like growth factor binding proteins. Horm Res. 1997; 48(Suppl 4):9-15 (review). PubMed 9350439

3. Lee PD, Conover CA, Powell DR. Regulation and function of insulin-like growth factor-binding protein-1. Proc Soc Exp Biol Med. 1993 Oct; 204(1):4-29. PubMed 7690486

4. Hills FA, Gunn LK, Hardiman P, Thamaratnam S, Chard T. IGFBP-1 in the placenta, membranes and fetal circulation: Levels at term and preterm delivery. Early Hum Dev. 1996 Jan 5; 44(1):71-76. PubMed 8821897

5. Hills FA, English J, Chard T. Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: Relation to birthweight and maternal weight. J Endocrinol. 1996 Feb; 148(2):303-309. PubMed 8699144

6. Grobman WA, Kazer RR. Serum insulin, insulin-like growth factor-I, and insulin-like growth factor binding protein-1 in women who develop pre-eclampsia. Obstet Gynecol. 2001 Apr; 97(4):521-526. PubMed 11275021

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Transfer the serum into a LabCorp PP transpak frozen purple tube with screw cap (LabCorp N° 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.