MHPG (3-Methoxy-4-Hydroxyphenylglycol), 24-Hour Urine

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Turnaround Time: 10 - 14 days
CPT Code:


Test Type: 10 mL Urine (24-hour)


Monitor levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG), a metabolite of norepinephrine. Patients with either high or low levels of MHPG have demonstrated marked sleep disturbance, which may be related to unipolar depression.1

1. Samson JA, Mirin SM, Griffin M, Borrelli D, Schildkraut JJ. Urinary MHPG and clinical symptoms in patients with unipolar depression. Psychiatry Res. 1994 Feb; 51(2):157-165. PubMed 8022950

Collection Details:

Collection Instructions:

Plastic urine container without preservative.


24-hour urine collection; submit an aliquot of the mixed 24-hour specimen and record total urine volume on test request form.

Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.