Multiple Myeloma Cascade With Reflex to sIFE and sFLC*

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Turnaround Time: 3 - 5 days
CPT Code:

84155; 84165

Test Type: 5 mL Serum
Stability Time:



Room temperature

3 days


14 days


14 days

Freeze/thaw cycles

Stable x3


To maximize the clinical sensitivity of Serum Protein Electrophoresis (SPEP) when screening for plasma cell dyscrasias.

The analytical sensitivity of the commonly used serum tests for Multiple Myeloma (MM) screening is: SPEP < sIFE < sFLC with SPEP being the least sensitive and sFLC being the most sensitive detector of M-proteins.1

According to the International Myeloma Working Group (IMWG) guidelines, addition of sFLC and IFE to SPEP can prevent false negatives and increases the detection of multiple myeloma to >99%.2

1. Katzmann, JA. Screening panels for monoclonal gammopathies: time to change. Clin Biochem Rev. 2009 Aug;30(3):105-111. PubMed 19841692

2. Dispenzieri A, Kyle R, Merlini G, et al. International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia. 2009 Feb;23(2):215-224. PubMed 19020545




Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Refrigerate at 2°C to 8°C.