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Register NowMultiple Myeloma Cascade With Reflex to sIFE and sFLC*
Create a Free Account to View PricesTurnaround Time: 3 - 5 days
CPT Code:
84155; 84165
Test Type: 5 mL Serum
Stability Time:
|
Temperature |
Period |
|---|---|
|
Room temperature |
3 days |
|
Refrigerated |
14 days |
|
Frozen |
14 days |
|
Freeze/thaw cycles |
Stable x3 |
Overview:
To maximize the clinical sensitivity of Serum Protein Electrophoresis (SPEP) when screening for plasma cell dyscrasias.
The analytical sensitivity of the commonly used serum tests for Multiple Myeloma (MM) screening is: SPEP < sIFE < sFLC with SPEP being the least sensitive and sFLC being the most sensitive detector of M-proteins.1
According to the International Myeloma Working Group (IMWG) guidelines, addition of sFLC and IFE to SPEP can prevent false negatives and increases the detection of multiple myeloma to >99%.2
1. Katzmann, JA. Screening panels for monoclonal gammopathies: time to change. Clin Biochem Rev. 2009 Aug;30(3):105-111. PubMed 19841692
2. Dispenzieri A, Kyle R, Merlini G, et al. International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia. 2009 Feb;23(2):215-224. PubMed 19020545
Collection Details:
Collection Instructions:
Red-top tube or gel-barrier tube.
Refrigerate at 2°C to 8°C.