Organix Comprehensive Profile (Urine) - Organic Acids Nutritional Test

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The Organix® Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body's cellular metabolic processes. Additionally, children's reference ranges are designed to provide more accurate pediatric nutritional evaluations. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes.

Organic Acids and Nutritional Testing
Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the biomarkers are markers of intestinal bacterial or yeast overgrowth.

The Organix® Comprehensive nutritional test profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining:

  • Functional vitamin and mineral status
  • Amino acid insufficiencies like carnitine and NAC
  • Oxidative damage and antioxidant need
  • Phase I & Phase II detoxification capacity
  • Functional B-complex vitamin need
  • Neurotransmitter metabolites
  • Mitochondrial energy production
  • Methylation sufficiency
  • Lipoic acid and CoQ10 status
  • Markers for bacterial and yeast overgrowth

Organic Acid Testing and Clinical Solutions:
Full review of the patient's biochemical status and metabolic pathway flow can help identify areas of greatest concern. Follow-up nutritional testing can monitor the effectiveness of selected treatments.

Advantages of the Organix® Comprehensive Profile

  • Extensive Analyte List - The Organix® Comprehensive Profile is a nutritional test which contains one of the most extensive biomarker lists in the industry. Including nutritional markers such as Quinolinate, D-Arabinitol, and 8-Hydroxy-2'deoxyguanosine, the Organix® offers great value.
  • Innovative Method - The LC/MS-MS method, which is also used to screen newborns for metabolic disorders, requires very little sample preparation and processing. This technology provides more stability, accuracy, and sensitivity in measuring organic acids at low levels for optimum test results.
  • Single Urine Specimen - A single overnight urine collection is easy for patients, leading to increased patient compliance.

The Organix® Comprehensive nutritional test is ideal for patients who may suffer from:

  • Weight issues
  • Sleep abnormalities
  • Depression
  • Chemical Sensitivities


Performing Lab: Genova

Collection Details:

Patient Preparation:

Patient Preparation

  • It is best to ship your specimen within 24 hours of collection. Please refer to the enclosed shipping instructions before you collect to determine what days you can ship your specimen.
  • It is not necessary to discontinue nutritional supplements prior to this specimen collection. Abnormalities that may be found will reveal special needs that have not been met by recent dietary and supplemental intake.
  • Decrease fluid intake to avoid excessive dilution of the urine
    » For adults, restrict intake to three 8 oz. glasses or less for 24 hours
    » Make sure that no more than 8 oz. of this is consumed after 8:00 PM the evening prior to urine collection
  • Do not collect urine during menstruation
  • Vial contains preservative - Do Not Rinse

Specimen Requirements

Overnight Urine, 12 ml, frozen

Collection Instructions:

1. Write patient’s first and last name, date of birth, gender and date of collection on
the Test Requisition Form (located in the pouch on top of the Specimen Collection
Kit Box), as well as on the clear-cap plastic vial, using a permanent marker.
• IMPORTANT: To ensure accurate test results you must provide the requested
2. Empty bladder before going to bed at night. Do not collect this urine.
3. Collect urine (if any) during the night and first morning urine into a clean container.
4. Pipette urine, using a fresh disposable pipette, into the clear-cap plastic vial to the
12 ml mark (DO NOT OVERFILL). Screw the cap on tightly.
5. Dispose of remaining urine.
6. Freeze the clear-cap plastic vial and ice pack.