Turnaround Time: 4-6 days
CPT Code:
  • 83520
Test Type: Kit-Based, Stool
Reference Range:


0-99 years 51-204 mg/dL


Immunological activity in the gastrointestinal tract can be assessed using secretory immunoglobulin A (sIgA). Secretory IgA is the predominant antibody, or immune protein the body manufactures and releases in external secretions such as saliva, tears, and milk. It is also transported through the epithelial cells that line the intestines out into the lumen. Secretory IgA represents the first line of defense of the GI mucosa and is central to the normal function of the GI tract as an immune barrier.

As the principal immunoglobulin isotype present in mucosal secretions, sIgA plays an important role in controlling intestinal milieu which is constantly presented with potentially harmful antigens such as pathogenic bacteria, parasites, yeast, viruses, abnormal cell antigens, and allergenic proteins. Secretory IgA antibodies exert their function by binding to antigenic epitopes on the invading microorganism, limiting their mobility and adhesion to the epithelium of the mucus membrane. This prevents the antigens from reaching systemic circulation and allowing them to be excreted directly in the feces.


Performing Lab: DDINT

Collection Details:

Patient Preparation:

Specimen Requirements
20 mL stool

Collection Container/Tube
Stool collection container

Transport Container/Tube
1 White-capped vial (Clean)

Minimum Specimen Volume
10 mL stool

Rejection Criteria
Not received cold
No ice pack

Stability Information
Room temperature: 2 days
Refrigerated: 7 days
Frozen: 14 days
37°C/99°F: Unacceptable