TRIAD Profile (Blood / Urine)

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Category:

Turnaround Time: 15-18 Days
CPT Code:

82139x39, 86001x90

Test Type: Kit-Based, Blood/Urine

Overview:

The TRIAD® Profile – Blood & Urine is a nutritional test that combines three key tests into one diagnostic solution. Imbalances or dysfunction in several metabolic areas can have overlapping and wide-ranging effects on health and play a causative role in many chronic conditions.

The Triad Profile – Blood & Urine assesses amino acids, organic acids, and IgG4 food antibodies and can provide guidelines for customized supplementation and dietary modification to improve health outcomes.

 

Clinical indications for testing include:

  • Food Sensitivities
  • Mood Disorders
  • Fatigue
  • Digestive Complaints
  • Weight Issues/Dietary Guidance

 

About the TRIAD Profile – Blood & Urine

Using a central blood draw and in-home overnight urine collection, the TRIAD Profile – Blood & Urine assesses an expanded menu of foods for those patients with suspected complex food sensitivities.

The complete TRIAD Profile – Blood & Urine assesses:

  1. IgG4 Food Antibodies 90 Profile (serum) – measures "delayed" reactions to 90 common foods
  2. 20 Amino Acids (plasma) – essential, conditionally essential, and non-essential amino acids, and key amino-acid ratios
  3. Organic Acids (urine) – nutrient markers, cell regulation markers, toxicants and detoxification markers, and compounds of bacterial or yeast/fungal origin

What Are the TRIAD® Profiles?

TRIAD® Profile – Blood & Urine or TRIAD® Bloodspot

As the name indicates, the TRIAD nutritional test integrates three informative nutritional tests into a single innovative profile. Available with either a central blood draw or a finger-stick bloodspot collection, both TRIAD profiles include:

    1. IgG4 Food Antibodies – measures "delayed" sensitivity reactions to common foods; either 90 foods (TRIAD Blood & Urine) or 30 foods (TRIAD Bloodspot)

    1. Organic Acids (urine)
      • Fatty Acid Metabolism
      • Carbohydrate Metabolism
      • Energy Production (Citric Acid Cycle)
      • B-Complex Vitamin Markers
      • Methylation Cofactor Markers
      • Neurotransmitter Metabolism Markers
      • Oxidative Damage and Antioxidant Markers
      • Detoxification Indicators
      • Bacterial – General
      • L. acidophilus/General Bacterial
      • Clostridial Species
      • Yeast/Fungal
      • Nutrient Markers
      • Cell Regulation Markers
      • Toxicants and Detoxification
      • Compounds of Bacterial or Yeast/Fungal Origin

  1. 20 Amino Acids (plasma [TRIAD Blood & Urine] or bloodspot [TRIAD Bloodspot]) – essential, conditionally essential, and non-essential amino acids, reported in clinically useful categories:
    • Limiting Amino Acids
    • Branched Chain Amino Acids
    • Other Essential Amino Acids
    • Conditionally Essential Amino Acids
    • Vascular Function
    • Neurotransmitters and Precursors
    • Sulfur Amino Acids (Glutathione-related)
    • Urea Cycle and Ammonia Detoxification
    • Ratios
    • Essential Amino Acids
    • Amino Acid Functional Categories

When Should a TRIAD Profile be Considered?

Patients with chronic symptoms may benefit from assessment of (1) reactivity to regularly eaten foods that may be producing chronic symptoms, but which are unsuspected due to a delay in onset of symptoms after consumption of offending food, (2) urine organic acids to evaluate specific metabolic pathways and biomarkers of enzyme vitamin and mineral cofactor need, and (3) amino acids in blood to assess protein status and utilization.

Clinical indications for testing include:

  • Food Sensitivities
  • Mood Disorders
  • Fatigue
  • Digestive Complaints
  • Weight Issues/Dietary Guidance

Performing Lab: Genova

Collection Details:

Patient Preparation:

Patient Preparation

Blood Collection - 

  • It is best to ship the specimen within 48 hours of collection. Please refer to the enclosed shipping instructions before you collect to determine the days that the specimen can be shippped.
  • Please check to make sure the patient has fasted prior to drawing blood.
  • The use of immunosuppressive drugs, like cortisone, can give false negative test results. The use of such drugs should be discontinued for 60 days before testing to allow antibody reactions to be seen.

Urine Collection -

  • It is best to ship the specimen within 48 hours of collection. Please refer to the enclosed shipping instructions before you collect to determine the days that the specimen can ship.
  • It is not necessary to discontinue nutritional supplements prior to this specimen collection. Abnormalities that may be found will reveal special needs that have not been met by recent dietary and supplemental intake.
  • Decrease fluid intake to avoid excessive dilution of the urine. - For adults, restrict intake to three 8 oz. glasses or less for 24 hours - Make sure that no more than 8 oz. of the fluid is consumed after 8:00 the evening prior to urine collection.
  • Do Not collect urine during menstruation.
  • Please check to make sure the patient has fasted prior to drawing blood
  • The use of immunosuppressive drugs, like cortisone, can give false negative test results. Discontinue the use of such drugs for 60 days before testing to allow antibody reactions to be seen.
  • Vial contains preservative - Do Not Rinse.

Collection Instructions:

Blood collection:

1. Write patient’s first and last name, date of birth, gender, and date of collection on the Test Requisition Form (located in the pouch on top of the Specimen Collection Kit Box), as well as on all tube(s) and/or vial(s), using a permanent marker.
IMPORTANT: To ensure accurate test results you MUST provide the requested
information.

2. Freeze the ice packets.

3. Red/gray top serum separator tubes and red top amber transfer tube:
- Draw the red/gray top serum separator tube.
- Place upright in a rack at room temperature for 20 to 30 minutes to clot blood.
- Centrifuge the red/gray top serum separator tubes for 15 minutes. The serum must be free of hemolysis or red blood cells.
- Pipette 3 ml serum, using a fresh disposable pipette, from the red/gray top serum separator tube into the red top amber transfer tube. Cap tightly.
- Refrigerate the red top amber transfer tube.

4. Lavender top EDTA tube and lavender top clear transfer tube:
- Draw the lavender top EDTA tube completely. - Invert the lavender top EDTA tube 10 times to mix the EDTA with the blood.
- Centrifuge immediately for 15 minutes. The plasma must be free of hemolysis or red blood cells.
- Remove the lavender top EDTA tube after centrifuging; DO NOT INVERT TUBE.
- Pipette plasma, using a fresh disposable pipette, 2.5-3 ml into the lavender top clear transfer tube.
- Freeze the lavender top transfer tube.

Specimen Preparation:

5. Place the frozen transfer tube, refrigerated red top amber transfer tube, and frozen
urine collection into the slots or the ends of the plastic shell tube tray (an exact fit is not necessary). Place absorbent pad over tubes. Place frozen ice packets at each end of tubes in tray. Snap the tray closed.

6. Place the tray into the biohazard bag.

7. Seal the biohazard bag; Place it into the specimen collection kit box and close the box.

Urine collection:

1. Write patient’s first and last name, date of birth, gender, and date of collection on the Test Requisition Form (located in the pouch on top of the Specimen Collection Kit Box), as well as on all tube(s) and/or vial(s), using a permanent marker.
IMPORTANT: To ensure accurate test results you MUST provide the requested information.

2. Empty bladder before going to bed at night. DO NOT collect this urine.

3. Collect urine (if any) during the night and first morning urine into a clean container.

4. Pipette urine, using a fresh disposable pipette, into the clear cap plastic vial to the 12 ml mark (DO NOT OVERFILL). Screw the cap on tightly.

5. Dispose of the remaining urine.

6. Freeze the clear cap plastic vial and the ice packet.