Turnaround Time:
CPT Code:
Specimen Type: Kit Based - Blood Draw
PURPOSE: Screening procedure to determine existing reaction with components of dental and orthopedic restoratives, irrespective of initiating source; facilitate selection of least offensive restorative products for individual patients.

TEST BASIS: Passive antibody detection by precipitin method, present at or above a relevant threshold to eliminate noise effects from casual contact.


ANTIGENS: 94 chemical groups and families of compounds.

REQUESTED SPECIMEN: 2-3ml separated serum; plasma can be used if necessary.

RELIABILITY: >95% on sequential multiple specimens.

PRECISION: >97% on multiple aliquots from the same specimen.

DETERMINATION OF PRODUCT SUITABILITY: Based upon material components in dissociable, ionizable, releasable, bio-available, or bio-convertible form.

REPORTING: Positive or negative determination for 94 basic chemical groups and families of compounds; correlation of findings with more than 17,204 dental restorative trade name products in 37 application categories, and more than 10,427 orthopedic restorative trade name products in 34 application categories, arranged both categorically and alphabetically.


  • Severe immune incompetence which precludes the normal generation of antibody
  • Heavy long-term immuno-suppression by medication or otherwise
  • Universal reactor status wherein reactions do not involve normal antigen processing cascades and antibody generation
  • Restricted usefulness in children without a mature immune record
  • Hyperactive non-specific immunoglobulin generation


  • Crossover between haptens (especially metals)
  • Hyper-reactive serum proteins lacking specificity
  • Long-term specimen holding without adequate refrigeration/freezing
  • Microbial overgrowth


  • Antibody titers below detection limits
  • The onset of high tolerance to immunogens
  • Failure to process antigen and induce systemic antibody


Clifford Materials Reactivity Testing Antigen Challenge List

  • Acetates Group
  • Acrylates Group
  • Aluminum Group
  • Antimony Group
  • Arsenic Group
  • Barium Group
  • Benzil Group
  • Benzylkonium Chloride
  • Beryllium Group
  • Bis-GMA I Bis-Phenols
  • Bismuth Group
  • Boron Group
  • Butyraldehydes Group
  • Butyrates Group
  • Cadmium Group
  • Carboxylate Group
  • Cellulose Group
  • Cerium Group
  • Cesium Group
  • Chromium Group
  • Cobalt Group
  • Copper Group
  • Eugenol
  • Europium Group
  • Flourides Group
  • Formaldehyde
  • Gallium Group
  • Germanium Group
  • Gluteraldehydes Group
  • Gold Group
  • Hafnium Group
  • Hexanes Group
  • Hydroxyapatite Group
  • Indium Group
  • Iridium Group
  • Iron Salts / Oxides Group
  • Lactides Group
  • Lanthanum Group
  • Lead Group
  • Lithium Group
  • Malienate Group
  • Manganese Group
  • Mercury Group
  • Metabisulte
  • Methyl Paraben
  • Molybdenum Group
  • Neodimium Group
  • Nickel Group
  • Niobium Group
  • O-Phosphoric Acid Group
  • Osmium Group
  • Oxylate Group
  • Palladium Group
  • Phenols Group
  • Platinum Group
  • Polyethers Group
  • Polyethylimines Group
  • Polysuldes Group
  • Polyvinyls Group
  • Propionates Group
  • Pthalates Group
  • Quinone Group
  • Rhenium Group
  • Rhodium Group
  • Rubidium Group
  • Ruthenium Group
  • Samarium Group
  • Scandium Group
  • Selenium Group
  • Silanes Group
  • Silicates Group
  • Silver Group
  • Sorbates Group
  • Strontium Group
  • Styrenes Group
  • Tannins Group
  • Tantalum Group
  • Tellurium Group
  • Terbium Group
  • Thallium Group
  • Thimerosal
  • Tin Group
  • Titanium Group
  • Toluenes Group
  • Trihexalamines Group
  • Tungsten Group
  • Uranium Group
  • Urethanes Group
  • Vanadium Group
  • Xylenes Group
  • Ytterbium Group
  • Yttrium Group
  • Zinc Salts Group
  • Zirconium Group

Collection Details

Collection Instructions:
Patient Preparation:
Follow the link below for Patient Test Prep Instructions:

ELISA/ACT CMRT Instructions

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